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+6½ -105+6½ -105  +6½ -105

Posted at 11:00AM EST and odds are subject to change.

Arizona +6 over Kansas City

4:25 PM EST. Patrick Mahomes needs no introduction here, but the rest of the Chiefs offense minus Travis Kelce might. Out is Tyreek Hill, who bolted for the big money in Miami. In is Marquez Valdes-Scantling, formally of the Packers. That’s a downgrade. We are about to find out what happens when you take away one of the most dynamic wide receivers in the game from your franchise pivot.

We are going to move on right to the Cardinals because this is where this game gets interesting. For those that do not know, Arizona head coach Kliff Kingsbury was the man who recruited Mahmoes to Texas Tech and coached him there. Kingsbury knows Mahomes inside and out. He’s the one that arguably developed Patty into the player he is today. That might be laying it on a little thick, but you get our point.

The Cardinals’ stock is down for many reasons, most notable—injuries to their defense and the suspension of star WR DeAndre Hopkins, who is serving six games for PEDs. Those absences might be significant, but they have also no doubt been factored into a line that opened with the Chiefs spotting just a field goal in the desert. Now, this line has been inflated to the price you see today. The injury chasers are out. As an aside, the Chiefs have their own problems on defense and will be starting rookie Trent McDuffie at CB1, which will likely see him lined up across from Arizona’s newest speedster.

This is a “next man up” league. Rarely do we fear an injury or loss of any player. Even the starting QB. Last we checked though, Kyler Murray is upright and healthy and he’s got a new toy with the uber-fast Marquise “Hollywood” Brown coming over from Baltimore. Brown likely can’t wait to run in an offense that will allow him to show what he can do with a real quarterback that can air it out (full offense to Lamar Jackson). Brown is tailor-made for Kingsbury’s Air Raid. Run, Hollywood, run.